Table of Contents

① Introduction to “Astragalus Polysaccharide” and its benefits

② Introduction to “Mushroom Polysaccharides” and its benefits

③ Introduction to “Echinacea” and its benefits

④ Introduction to “colostrum” and its benefits

⑤ Introduction to “Transfer Factor” and its benefits

⑥ Introduction to "Mannan Peptide" and its benefits

Introduction to "Astragalus polysaccharide" and its benefits

Introduction: Astragalus polysaccharide is purified from the traditional Chinese medicine Astragalus membranaceus and consists of hexuronic acid, glucose, fructose, rhamnose, arabinose, galacturonic acid and glucuronic acid.

Benefits:
It can be used as an immune promoter or regulator, and has anti-viral, anti-tumor, anti-aging, anti-radiation, anti-stress, antioxidant and other effects.
① Can significantly enhance non-specific immune function and humoral immune function;
② Can significantly promote the antibody production function of the normal body;
③ Enhance lymphocyte immune function;
④ Protect target cells against T cell activity and improve NK cell activity;
⑤ It has obvious effects on inducing and promoting the activity of the interferon system.

Related experiments/documents:

"The Effect of Astragalus Polysaccharide on Canine Immune Indicators", Shandong Animal Husbandry and Veterinary Medicine, Issue 11, 2009
"The Role of Astragalus Polysaccharide in Immunoregulation", Anhui Medicine, Issue 07, 2008
"The Effect of Astragalus Polysaccharide on Lymphocyte Subpopulations in Healthy Subjects", Compilation of Papers of the 10th Army Laboratory Medicine Academic Conference, 2005
"The Anti-tumor Effect of Astragalus Polysaccharide" "Progress in Basic Research", Proceedings of the 2012 Fifth National Clinical Symposium on Traditional Chinese Medicine, 2012
"The regulatory mechanism of astragalus polysaccharide on vaccine immunity", Veterinary Guide, Issue 02, 2011

Summary :

Astragalus polysaccharide has a long history of application in the pet industry, and there are many related products. Parents giving an appropriate amount of astragalus polysaccharide during the vaccine period will help improve the success rate of vaccine immunity.
Remember: Astragalus polysaccharide is not always better when given, nor is it suitable for long-term consumption. It’s better to just buy the ones just for pets.Otherwise, if you fail to control the dosage, you will fail to improve your immunity and may end up with side effects.

Introduction to “Mushroom Polysaccharides” and its benefits

Introduction: Water-soluble proteoglycans extracted from mushroom fruiting bodies are The main active ingredient of mushroom polysaccharide.
Benefits:
① It is a good immune enhancer, which can enhance the function and recognition ability of immune cells and increase the amount of IgM
② It has strong anti- Cancer activity, especially gastric cancer and ascites cancer, can inhibit the growth of tumor cells and absorb and excrete carcinogens
Types: Ganoderma lucidum polysaccharide, Versicolor polysaccharide, mushroom polysaccharide, and shiitake mushrooms Polysaccharides, matsutake polysaccharides, tea tree polysaccharides, oyster mushroom polysaccharides, enoki mushroom polysaccharides, etc.
The two mentioned above are the common benefits of mushroom polysaccharides. Depending on the specific source of raw materials, mushroom polysaccharides have other corresponding effects, which will not be introduced in detail in this article.

Related experiments/documents:

"Study on the molecular mechanism of K562 tumor cell apoptosis induced by Brazilian mushroom polysaccharide (ABPS)", Yuan Liming, 2005
"Effects of Lentinan on Normal Mice And the impact of immune function in immunosuppressed mice", Journal of Gansu College of Traditional Chinese Medicine, Issue 04, 2004
"Effects of Ganoderma lucidum polysaccharide peptides on lung cancer cell invasion", Journal of Peking University (Medical Edition), Issue 06, 2007
/>"Effects of Polysaccharide from Versicolor Versicolor on Growth and Immune Function of Tilapia Ornithus", Huazhong Agricultural University, 2007 Comparison of immunomodulatory activities of mouse spleen lymphocytes and peritoneal macrophages", Journal of Peking University (Medical Edition), Issue 06, 2005

Summary:

Is this type of product rarely seen in China? The first time I learned about mushroom polysaccharides was when I browsed overseas shopping mall websites. At that time, I read the introduction and customer reviews (similar to Taobao reviews) and found that it mainly improves immunity and is widely used in adjuvant anti-cancer treatment.
A few days ago, an eleven-year-old golden retriever who was fighting cancer came to our group, which reminded me of "mushroom polysaccharides" again. There are many mushroom polysaccharide products in the United States, both for humans and pets. Parents who need them can go over the wall to find them.
Many experts include mushrooms in the prohibited list for dogs. In fact, this is to prevent them from eating poisonous wild mushrooms when they get used to eating shiitake mushrooms, which may cause poisoning. In fact, non-toxic mushroom derivatives are available in foreign pet medical products.
However, mushroom polysaccharides are really expensive.
Note: The effect of mushroom polysaccharides is parabolic, and it does not mean that the more you give, the better. Don’t know how much to feedIf it's too much, it may be a waste of money.

Introduction to "Echinacea" and its benefits

Introduction: Also known as "Echinacea", it grows in the Americas (is it available in China? I didn't check), it can be used for medicinal purposes.
Benefits: It can stimulate the vitality of white blood cells and other immune cells in the human body, and has the effect of enhancing immunity. It is often used to assist in the treatment of colds, coughs and upper respiratory tract infections.
Common products:
Childlife Echinacea Drops (imported from the United States), KCH Echinacea Chewable Tablets (imported from Europe), Kiwiherb Children Baby organic echinacea drops (imported from New Zealand), Puritan's Pride echinacea capsules (imported from the United States), GNC echinacea essence capsules (imported from the United States), etc. The above list are all products for human use.
Because foreign countries focus on improving their own immunity against viruses and strictly control the use of antibiotics, echinacea products are basically imported.
Related experiments/documents:
"Study on the Effect and Mechanism of Echinacea Extract on the Immunity and Resistance to Salmonella Infection in Mice", Zhejiang University, 2014
"Effects of Echinacea Extract on Mice "Influence on immune function", Jiangsu Agricultural Science, Issue 03, 2011
"Research Progress of Echinacea and its Application Prospects in Animal Health", Veterinary Drugs and Feed Additives, Issue 03, 2006
"Activities of Echinacea and Astragalus "Study on the components of Echinacea purpurea volatile oil components and its anti-inflammatory, antibacterial and antioxidant effects", Anhui Agricultural University, 2010
h3>Summary:Can Echinacea be used on pets? Yes, there are related products both at home and abroad.

Introduction to "colostrum" and its benefits

Introduction:The milk from a cow within 3 days after calving is called "colostrum" . Bovine colostrum contains a large number of immune factors and growth factors, such as immunoglobulins, lactoferrin, lysozyme, insulin-like growth factors, epidermal growth factors, etc.
Benefits:
① Enhance immunity
② Inhibit a variety of pathogenic microorganisms
Effectiveness indicators: Immunoglobulin ( IgG), domestic regulations cannot be less than 10%, and imported ones are generally around 20%.
Production methods:Freeze-drying
Taboos: Low temperature throughout the process, avoid medium and high temperatures.
Related experiments/documents:
"Research on the immunity-enhancing function of immunoglobulin IgG in bovine colostrum powder", Modern Food, Issue 17, 2018
"Bovines rich in miR-30a Colostrum components promote tumor death after cisplatin chemotherapy by inhibiting cancer cell autophagy", Advances in Biochemistry and Biophysics, Issue 11, 2012
"Immune-modulating functional food—bovine colostrum", Chinese Food and Nutrition, Issue 05, 2006
"The effects of aerobic exercise combined with bovine colostrum intake on T lymphocyte subsets and salivary IgA in adolescents", Genomics and Applied Biology, Issue 12, 2017
"Bovine Experimental study on the anti-aging effect of colostrum powder", Chinese Journal of Gerontology, Issue 06, 1999

Summary:

When I mention bovine colostrum, I think of the magical "bovine colostrum" "Dog food", I don't know if those dog foods really contain "colostrum", but based on the research on bovine colostrum, I suggest parents to buy colostrum products directly, which will be more beneficial than "cow colostrum dog food" .
Question 1: Bovine colostrum should be avoided at medium to high temperatures, as medium temperatures can destroy its active ingredients; while milk powder is difficult to dissolve in fat, it is common in dog food on the market. They are all wrapped in a layer of "animal fat + food attractant balm". I wonder how "colostrum dog food" can avoid medium and high temperatures while being evenly distributed on the oily surface?
Question 2: Bovine colostrum is really expensive. Take a look at the human colostrum products on the market


Brand:Tomson Colostrum Plus Calcium Chewable Tablets
Ingredients: Bovine colostrum, calcium, etc., not fully labeled.
Calculation of net content of bovine colostrum:
The active ingredient index of bovine colostrum is based on IgG (immunoglobulin G), because two of the listed products are imported (Imported bovine colostrum IgG is generally 20%), and two domestically produced (IgG indicators are stated to be 18-20%). Since this BY-HEALTH bovine colostrum is only marked "contains 2.97 grams of IgG per 100 grams" , we assume that the colostrum contains 20% IgG, and each 100 grams of the product contains 14.85% of colostrum~
And a set of three bottles of product is "72g+36g+36g”, 144 grams in total.
The net content of colostrum in this product is: 144*14.85%=21.384g
The price of colostrum per gram of this product:5.19 yuan


Brand:American Childhood Colostrum Powder
Ingredients:Colostrum, rice solubles, FOS protein, probiotics
Calculation of bovine colostrum net content:
Each 2 grams contains 1400 mg of bovine colostrum, that is, the content is 70%~
One bottle 50 grams, containing colostrum = 50*70% = 35 grams
The price of this product per gram of colostrum:4.886 yuan

< br />Brand:Naturies New Zealand colostrum powder
Ingredients:Colostrum powder, whey protein powder, fructooligosaccharides, galactooligosaccharides< br />Calculation of bovine colostrum net content:
Because this product does not directly label the bovine colostrum content and IgG content, it only labels the galacto-oligosaccharide content, each containing 0.15 grams. Because the cost arrangement of foreign products is strictly based on content, galacto-oligosaccharide ranks last, which means the lowest content; the content of "whey protein" and "fructo-oligosaccharide" in front will only be higher than 0.15 grams per product. Bag.
Based on the minimum content of "whey protein" and "fructo-oligosaccharides", a 1-gram pack of product contains at least 0.45 grams of the total of these three items. In other words, the content of bovine colostrum is <55%
The content of bovine colostrum in a 30-gram box: 30g*55%=16.5g
That is, the bovine colostrum contained in a box, the maximum More than 16.5 grams.
The price of this product per gram of colostrum:25.93 yuan (so expensive)

Brand: strong>Amend brand colostrum powder
Ingredients:Colostrum powder
Calculation of net content of colostrum:
100g contains 18 grams of IgG is made in China. This is basically pure colostrum powder.
The packaging box says 20 grams per box.

The price of this product per gram of colostrum: 6.9 yuan

Brand: Naijer brand colostrum powder
< strong>Ingredients:Bovine colostrum powder
Calculation of bovine colostrum net content:
Pure, the introduction also specifically emphasizes “only bovine colostrum”.
The packaging box says 18 grams per box, special price 299 yuan, calculated based on the special price.
The price of this product per gram of colostrum:16.611 yuan (a bit expensive)
Through the previous calculations, we can know that the price of colostrum is the cheapest. It costs about five yuan per gram, which is equivalent to 2,500 yuan per pound! ! !
So, if parents choose "colostrum dog food" to improve immunity, it is best to calculate the price and cost to see if they are equivalent~

< br />Introduction to "transfer factor" and its benefits

Introduction: Also known as "transfer factor", it is used by the immune system to mark infected cells. cells will be attacked by T cells.
But in fact, due to technical reasons, the scope of application is still very limited. In China, it is mostly used to help children with leukemia develop immunity to the herpes virus, while in the United States, it is classified as a "medicinal diet".
Benefits:
① Trigger and regulate cellular immune function, sensitize cells that have not been exposed to antigens, and differentiate and proliferate T lymphocytes into effector T cells
② Activate macrophages and enhance collaborative participation The ability of immune response macrophages to recognize, bind, phagocytose and digest antigens
③ Improve the production of various cytokines such as interleukin II, interferon and other human factors in the body

Related experiments/documents:

"Study on the mechanism of transfer factor in enhancing canine cellular immune function", Northwest A&F University, 2005
"Preparation of canine-specific transfer factor and detection of its immune activity", Advances in Veterinary Medicine, Issue S1, 2010
/>"Research and Clinical Application of Transfer Factors", Journal of Biology, Issue 05, 1997
"Research Progress of Transfer Factors in Animal Medicine", Hubei Animal Husbandry and Veterinary Medicine, Issue 06, 2003
"Transfer Factors" Research Status", Poultry Science, Issue 08, 2018

Summary:

Transfer factors are generally extracted from pigs, cattle and sheep, and are freeze-dried. The virus cannot be completely eliminated, especially if it can be transmitted to Dog viruses, so there is a certain danger.
Not recommended unless necessaryEasy to use this. When choosing, try to avoid pig sources to avoid being infected with the "pseudorabies" virus from pigs.

Mannan peptide

Introduction:Mannan peptide (Mannatide) was formerly known as polyanti-A, and is mostly extracted from Konjac. It is the first immunity-enhancing drug in China. In China, it is mostly used as adjuvant treatment against tumors.
Benefits:
① It can activate phagocytes, NK cells, and T.B cell subsets;
② It can induce interferons and interleukins;
③ Can break the chromosomes of tumor cells, viruses, etc., causing them to undergo apoptosis;
④ Can induce a variety of effector cells and cytokines to produce a "cytokine cocktail" effect, broad-spectrum killing of viruses, pathogenic bacteria, and Broad spectrum induces tumor cell apoptosis.
Related experiments/documents:
"Systematic review of the clinical efficacy and immune function effects of mannan peptides on recurrent respiratory tract infections", Chinese Journal of Evidence-Based Medicine, 2014 06 Issue
"Analysis of factors related to severe allergic reactions caused by mannan peptides", Chinese Journal of Hospital Pharmacy, Issue 11, 2014
"Clinical evidence-based study of mannan peptides in the supportive treatment of malignant solid tumors", Chinese Journal of Hospital Pharmacy, Issue 01, 2012
"Effects of Mannan Peptides on Immune Function in Patients with Head and Neck Tumors", Chinese Journal of Gerontology, Issue 22, 2011
"Effects of Mannan Peptides on Lymphatic Hematopoiesis" Clinical meta-study of supportive treatment of systemic tumors", Chinese Journal of New Drugs, Issue 24, 2011
"Research progress on the anti-tumor effect of mannan peptides", Northwest Journal of National Defense Medicine, Issue 8, 2017
Summary:
First of all, mannan peptides are not cheap. Secondly, at the beginning, I did not plan to write about "mannan peptide" in this article. When it was almost finished, I hesitated for a long time and added it. Because this product is the first of its kind in my country, coupled with the high price, there is basically no precedent for its application in pet medical treatment, and...there are no relevant records abroad.
So, I suggest that if it is not a case of "tumor" or "cancer", you should not try mannan peptide on your dog easily.
If you really need to use it, remember to test for allergies first. There are many reports of severe allergies among domestic people. After all, this is a new drug.
Note: This medicine is not suitable for long-term use. There are treatment requirements, please check carefully yourself.