I don’t know if you still remember the heart-warming Japanese movie "Goodbye, Keru"? The editor cried every time I watched it, especially when the dog was gradually approaching the end of his life, and he had a lot of runny noses. Holding the tissue box in tears and grieving. Because of this touching guide dog movie, it sparked a whirlwind of raising Labrador dogs, and also made more people pay attention to the great mission entrusted to guide dogs. Governments, stores, and public facilities have also become more humane. Provide living space for guide dogs and blind people.

Although it occasionally happens that stores prohibit guide dogs from entering, the movie has deeply affected the public. People will help to uphold justice and report stores, which greatly improves the quality of life of guide dogs and blind people. However, when everyone is flocking to raise Labradors, have they done their homework properly? The more inbred animals are, the more likely they are to have genetic defects (so don’t have the myth of raising famous dogs or purebred dogs) ), Labrador retrievers are one example. They have the genetic defect of hip dysplasia. As in the second half of the movie, Kelu suffers from hip dysplasia and walks more and more slowly and stops. , and even limped. Later, he fell and was seriously injured because he didn't step on the steps properly when going down the stairs. Finally, he was released in the warm embrace of his owner.

Most purebred dogs have congenital genetic defects, such as Dalmatians with congenital deafness, Poodles with epilepsy, Boxers with malignant tumors, and Doberman Pinschers with bleeding problems similar to hemophilia. There are about 22 types of dogs with congenital genetic defects related to vision:

Miniature long-haired dachshund, Norwegian elkhound, Irish setter, Miniature schnauzer, Miniature poodle, toys Toy poodle, Chesapeake Bay retriever, Labrador retriever, American cocker spaniel, English cocker spaniel, United Kingdom English springer spaniel, Siberian Husky, Sloughi, Briard, Old English mastiff, Bull mastiff , Samoyed, Tibetan terrier, Cardigan Welsh corgi), Australian cattle dog (Australian cattle dog), Irish wolfhound (Irish wolfhound), Japanese Akita (Japanese Akita).

The most common ophthalmic genetic defect among the 22 types of dogs mentioned above is commonly known as PRA or gPRA (Canine Generalized Progressive Retinal Atrophy). The full name is Canine Generalized Progressive Retinal Atrophy, or Canine Genetic Retinal Degeneration in short. Among dog eye diseases, which is an important cause of retinal disease and blindness in dogs, PRA will occur in both eyes at the same time, but it will not cause pain. Fortunately, if there is an owner who raises a purebred dog that happens to be listed in the above 22 species, there is no need to be too nervous, because if the DNA of the family pedigree does not contain the PRA mutant gene, or its dog from several generations ago If none of the relatives show symptoms of PRA, the dog is not prone to the disease.

In addition, PRA does not necessarily only occur in the above-mentioned purebred dogs. PRA can occur in most breeds of dogs, as well as mixed-breed dogs. However, there are many different types of retinal degeneration in purebred dogs. disease. In studies of all breeds, PRA is recessively inherited; PRA is dominantly inherited in Old English mastiffs and Bull mastiffs, and is inherited in Siberian Husky, Samoyed dogs have sex-linked inheritance, so when dogs with sex-linked inheritance are diagnosed with PRA, they are all male dogs.