Cats need to be calmed when they are agitated

How to choose a cat sedative! What you need to know about cat sedation! Some neurological symptoms in cats are mostly caused by diseases, and many infectious diseases have arrived Corresponding neurological symptoms will occur in the later stage. Of course, this is a manifestation of serious neurological symptoms. Sometimes cats will suddenly become manic due to psychological depression, estrus, etc. At this time, in order to avoid greater harm, it is necessary to Calm your cat.

In some ways, music has a relaxing effect on cats and can reduce their aggressive behavior. Therefore, you can play your music with soft background music, which can also soothe cats. If it is a lonely old cat, you might as well add a kitten to keep it company. Because it is easier for an old cat and a young person to accept each other, but it should be noted that the kitten has to be brought home by someone the old cat never knows. This person is there in the hope that the old cat will not associate you with the kitten and become jealous.

In addition, when a cat feels nervous, it will naturally attack its enemies with its claws, so you need to trim your cat's nails frequently. It is best to have another person hold it while trimming. , to draw its attention.

Sedative selection

1. Alpha2 adrenergic antagonists

Alpha2 antagonists are used to reverse the sedation of alpha2 agonists. and cardiovascular effects. Currently, there are three antagonists: tolazoline, yohimbine, and atimazole. If relatively excessive amounts of antagonists are given, neurological (excitability and muscle tremors), cardiovascular (hypotension and tachycardia), and gastrointestinal (sialorrhea and diarrhea) related side effects may occur. Deaths have also been reported with rapid IV administration. The mechanism may be a rapid reversal of vasoconstriction to the sympathetic nervous system without sufficient time to increase CO, causing severe hypotension.

2. Benzodiazepine sedatives

Most of the pharmacological effects of benzodiazepines are accomplished by regulating GABA-mediated nerve conduction. In the cell membrane of mammalian central neurons, GABA is the main inhibitory neurotransmitter. These receptors are also found outside the central nervous system in autonomic ganglia. In neurotransmission, two types of GABA receptors are involved: The GABAA receptor complex is a ligand-gated chloride channel with five glycoprotein subunits surrounding a central pore. The benzodiazepine binding site, which is also the binding site for other injectable anesthetics (barbiturates, propofol, etomidate), is located within the GABAA receptor complex. Benzodiazepines enhance the binding of GABA and GABAA receptors, increasing the frequency with which the channels open. However, barbiturates enhance intrinsic activity and increase the duration of channel openness. Both mechanisms increase chloride ion conduction and cell membrane hyperpolarization, reducing neuronal excitability. In the absence of GABA, benzodiazepines have no intrinsic agonist activity and cannot alter chloride ions.of conduction. This lack of intrinsic activity to inhibit central nervous system activity (i.e., not inhibiting CNS excitability) gives benzodiazepines a wider safety range than barbiturates. There are three types of ligands that bind to benzodiazepine receptors: agonists, reverse agonists, and antagonists. Agonists bind to benzodiazepine receptors and produce sedative, anxiolytic, muscle relaxant, and antispasmodic effects in most animals. Reversal agonists bind to the same receptors and produce opposite effects. Antagonists have high affinity for benzodiazepine receptors and have little or no intrinsic activity. Antagonists block or reverse the effects of agonists and reverse agonists and reverse agonists. Diazepam, midazolam, and zolazepam are all benzodiazepine agonists commonly used in veterinary clinical practice. Diazepam and midazolam are primarily used as sedatives, muscle relaxants, and antispasmodics. Zolazepam can be combined with a dissociative anesthetic (tiletamine) and is an approved anesthetic product in cats in the United States.